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The user interface is based on a 10” multi-touch display that lets users track progress of the method, know about events or conditions that need attention, and perform any necessary manual operations such as flushing the channel. It incorporates four highly precise and stable flow controllers that ensure robust and repeatable fractionation runs, without the associated pulsation and inherent complexity and low reliability of the multiple pumps found in other FFF systems.Įclipse supports both tip injection and focus-zone injection, enabling use of a variety of FFF separation channels and even a size-exclusion chromatography column. The Eclipse FFF instrument is the heart of the FFF system. The Mobility ™ add-on system expands Eclipse’s capabilities to include measurements of charge and zeta potential. Advanced features include the Dilution Control Module ™ (DCM) and the ability to switch seamlessly between FFF and size-exclusion chromatography (SEC) separations. Eclipse brings FFF to a completely new level, combining exquisite performance and ease of use. The Eclipse ™ system is the foundation of FFF-MALS, a powerful technique for separation and comprehensive characterization of macromolecules and nanoparticles from 1 to 1000 nm in size. Separation of biotherapeutics can usually be done in full formulation buffer. The ultimate separation system for nanoparticles and macromolecules Uniquely Versatileįield-flow fractionation is a uniquely versatile means of size-based separations, capable of fractionating viral particles, liposomes and lipid nanoparticles, emulsions, proteins and aggregates, polysaccharides and technical polymers, engineered nanoparticles, colloidal soil suspensions, chemical mechanical polishing slurries, and many more - with no stationary phase and almost no shear.